top of page

Research

Spiegel Lab and others extend the field of TPD through bifunctional molecules that target extracellular proteins for endocytosis and subsequent lysosomal degradation, termed as Molecular Degraders of Extracellular proteins (MoDEs), or LYTACs.

MoDE

MoDE binding to target protein in human body illustration

MoDE

  • Extracellular protein targets are eliminated via the asialoglycoprotein receptor (ASGPR)

  • Harnesses the body’s own machinery (liver) for degrading proteins  

Diagram showing a bifunctional molecule that binds liver ASGPR and anti-DNP antibody

Caianiello DF; Spiegel DA, et al. Nat. Chem. Biol., 2021, 17, 947-953

bottom of page